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Of note, 65% (701 genes) of genes with significant DoTT (5-fold change in 4sU-seq signal downstream/upstream of PAS) in ICP27-expressing cells also displayed similar defect in HSV-1-infected cells (Fig

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This was just confirmed by my colleague, Keith Humphreys, at Stanford

Without them, the off-target activity looks a lot more like GHRP-2

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