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Theres less collagen and elastin, slower cell turnover, a thinner dermis, and hormonal shifts like lower estrogen that affect your skins barrier and structure

References: Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P

10.1210/jc.2017-02153 J Clin Endocrinol Metab

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Savetsky I.L., Ghanta S., Gardenier J.C., Torrisi J.S., Garca Nores G.D., Hespe G.E., Nitti M.D., Kataru R.P., Mehrara B.J

Read our guide on how long semaglutide lasts in the fridge for additional storage details

For most vegans, those options work without ever needing an injection