As always, careful consideration of dosage, safety, and legal compliance is essential when exploring these compounds
Two mechanisms of reaction of these species with DNA and proteins are known: type I mechanism, involving one-electron transfer, and type II mechanism which can be divided into two subtypesmajor mechanism based on reaction with DNA via singlet oxygen, resulting in formation of 8-oxoguanine, and minor mechanism based on formation of a superoxide anion radical which undergoes disproportionation reaction, giving hydrogen peroxide and reactive oxygen species (IARC 2012)
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4 This means it can potentially be effective taken orally (as a pill) in addition to being used by injection
Disclosure The authors report no conflicts of interest in this work
Amir LR, Li G, Schoenmaker T, Everts V, Bronckers AL