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DOI: 10.1113/jphysiol.1934.sp003147 Gericke A et al (2011): Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

At the formulation level, developing novel drug delivery systems through structural optimization and nanotechnology represents a key priority, with glycyrrhizin-based nanocarriers already demonstrating improved oral bioavailability and hepatic targeting in preclinical studies (Xu et al., 2025)

However, this relationship is not straightforward and appears to be context dependent

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With regular use, your skin starts to feel stronger, smoother, and more refined