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Keap1 is an adaptor component of Cullin 3 (Cul3)-based ubiquitin E3 ligase that enhances the ubiquitylation of Nrf2, which promotes the degradation of Nrf2 in proteinsome (Uruno and Yamamoto, 2023

Singh, Centre for Bioinformatics, School of Biotechnology, for his assistance in the in silico study

While normal erythrocytes live 120 days, sickle erythrocytes typically last only 1020 days due to the processes of extravascular phagocytosis and intravascular haemolysis (Crosby, 2007)

Any decision about compounds like these belongs with a qualified clinician and within applicable law

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