cDNA was synthesized from 1 g of total DNA-free RNA using random hexamer primers and Superscript III reverse transcriptase (Life Technologies Carlsbad, CA, United State) following the manufacturer instructions
With respect to the newness criterion, the applicant stated that a new drug application (NDA) for CYTALUX was approved by FDA on November 29, 2021, as an optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions
Particular attention should be paid to possible side effects linked to the method of administration, like subcutaneous injections, which might cause local reactions such as redness, swelling, or irritation
This provides validation for the inclusion of glutathione synthetase, GshF, in the plasmid
Some peptides with hydrophobic domains may require initial dissolution in a dilute acetic acid solution before being diluted with bacteriostatic water
such designs are highly complementary to GSH-sensing strategies because they convert a biochemical signature into an amplified photodynamic response [20]
