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In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

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Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats

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demonstrated that curcumin suppresses aldosterone-induced C-reactive protein (CRP) production in vascular smooth muscle cells by inhibiting the ROS-ERK1/2 signaling pathway (Zhang et al., 2020a)