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Data availability A dataset with deidentified participant data and a data dictionary will be made available upon reasonable request from any qualified investigator, subject to a signed data access agreement

Long-term studies in laboratory models suggest that sustained NNMT inhibition may reprogram cellular metabolism toward enhanced oxidative capacity and improved stress resistance

A: Preclinical studies have explored concentrations from approximately 1 nM to 10 M in vitro, with in vivo models typically using formulations calibrated to deliver peptide within a physiologically relevant range at the wound site

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These findings may elucidate the elevated autoimmune response in IMDD patients, in which phospholipids, including anticardiolipin, antiphosphatidylserine, and antipartial thromboplastin autoantibodies, are targeted [54, 55]