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Tully, D

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We measured the global acyl-CoA content in the Gly and CKO groups and showed that PRMT1 knockdown in TECs increased acyl-CoA content, indicating increased fatty acid metabolism (Fig

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The acute decrease in UMP/UDP/UTP levels that resolves despite continued TS inhibition supports the hypothesis that an increase in nucleotide salvage might be linked to our observed mitochondrial phenotypes