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To examine this inhibitory effect in vivo, we employed real-time patch recordings to monitor small intestinal peristaltic waves by attaching a sensor on the small intestinal wall (Fig

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The advantage is eliminated reconstitution error

Age-dependent accumulation of dicarbonyls and advanced glycation endproducts (AGEs) associates with mitochondrial stress

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It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)