Drug Des Devel Ther 12:35353547 Dormer UH, Westwater J, McLaren NF, Kent NA, Mellor J, Jamieson DJ (2000) Cadmium-inducible expression of the yeast GSH1 gene requires a functional sulfur-amino acid regulatory network
Wouthuyzen-Bakker, M
Image : Hepatic synthesis of glutathione and nutritional substrates, co-factors, and other nutrients that influence metabolism
Tumors with high ASNS expression exhibit reduced responsiveness to immune checkpoint inhibitor therapy, and knockdown of ASNS promotes the programmed cell death protein 1 (PD-1) blockade efficacy [115]
70 Further research indicates that aside from inherent antimelanoma activity, NBDHEX also has the ability to enhance the function of temozolomide, with the two able to work synergistically to suppress tumor growth
Grossman CE, Akin O, Damato AL, Nunez DA, Zelefsky MJ