The B12 intravenous dose is usually the same as the intramuscular dose, from 1000 mcg to 2500 mcg per infusion
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Most resolve within hours to days and decrease with repeated doses
However, the flushing does not go away at a lower frequency, it just becomes less intense
No overall differences in safety were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in safety between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out