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Am J Physiol Ren Physiol 302:F141-149

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HYPERTENSION AND GLUTATHIONE-RELATED PARAMETERS OF OXIDATIVE STRESS Hypertension is associated with disturbances in glutathione metabolism

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This further supported its use in adjuvant chemotherapy and raided the scientific interest in finding new analogues with anti-estrogenic activity and no estrogenic effects and most important with potent PGS inhibitory actions [15]