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The joint capsule that encloses the knee can thicken and develop fibrosis

However, no significant ROS accumulation (neither mitochondrial SOX nor cellular ROS) was detected upon BSO treatment ( Supplemental Figure 2B )

These effects typically manifest over about three weeks, although the timeframe can vary based on the frequency of treatments and individual metabolism

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After that, the cell pellet was resuspended and subjected to three freezethaw cycles (liquid nitrogen and 37 C)