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These include: a) Aldh1a1, Aldh2, Aldh1b1, Cat, Cyp2e1, Adh3a1 and Gclm single knockouts (KO) b) Aldh1a1 and Aldh3a1 knock-in lines (both have mutated the Cys-302 of the active site) c) Aldh1a1/Aldh1b1, Aldh1b1/Aldh2, Cat/Cyp2e1 and Gclm/Nrf2 double knockouts (DKO) d) Conditional Gclc floxed strain e) Hepatocyte-specific Gclc knockout Funded by NIAAA (R24AA022057) Contact Please send inquiries and requests to: Dr

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For bulk RNA-seq data, we used the ssGSEA algorithm (the gsva function from the GSVA package v1.44.2) to integrate gene signatures and calculate the signature score for each sample

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As a skilled diagnostician, Dr

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