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12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones

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Rare cases have been reported of Boerhaave syndrome (ie, spontaneous esophageal rupture) or dilatation-induced perforation