The hinge and latch model is one of the attractive hypotheses for the sensing mechanism of the Keap1Nrf2 system
However, most degradation is invisible at the molecular level
GSH participates in cell signaling through at least two mechanisms, protein S-glutathionylation and cysteine S-nitrosylation through thiol exchange with GSNO
Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
Having worked closely with patients exploring different whitening solutions, from topical regimens to in-clinic procedures, I can tell you this: the longevity of skin whitening depends less on the treatment alone and more on your skin type, lifestyle, and maintenance routine
PS, JS, EO-N, and GL revised and edited the draft paper