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4.2.5 Oxidative stress and inflammatory response An increased abundance of Gram-negative bacteria in the gut of PCOS patients elevates circulating LPS, which activates the LPS/TLR4 pathway and sustains systemic chronic low-grade inflammation (73)

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Furthermore, relying solely on antioxidants for intervention proves inadequate in mitigating atherosclerotic events due to the intricate pathology of atherosclerosis 29

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