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Research demonstrates that NNMT expression increases significantly with advancing age, particularly in metabolic tissues, contributing to the progressive decline in NAD+ levels observed during aging

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Heres a quick breakdown our team put together to visualize the differences: So, for sciatica, which one makes more sense

A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

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