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doi: 10.3389/fimmu.2025.1699210 Received 05 September 2025 Revised 05 November 2025 Accepted 07 November 2025 Published 03 December 2025 Volume 16 - 2025 Edited by Stefan Tukaj, University of Gdansk, Poland Reviewed by Immadi Sudhakar Vamshidhar, All India Institute of Medical Sciences, India Alireza Arefzadeh, Islamic Azad University Central Tehran Branch, Iran Updates Copyright 2025 Murugan and Alzahrani

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The GSH:GSSG ratio, which serves as a marker for oxidative stress, calculated by metabolite abundance normalized to protein concentration was as follows: SCC9 = 219.1, Detroit562 = 241.8, SCC47 = 43.1, SCC104 = 225.2 (Fig

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