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no serious adverse reactions were reported in short-term healthy-adult research

Third, the compound has shown a favorable safety profile in preclinical studies

& Sinclair, D

2011;6: e28663

93 LEP enhances IL-1-induced production of MMP-1, MMP-3, and MMP-13 in human OA cartilage, 94 indicating its role as a catabolic regulator of cartilage metabolism