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When the membrane lipid was peroxided, the physical properties of lipid bilayers were altered: membrane fluidity was reduced, the ion gradient was destroyed, membrane permeability was elevated, and lateral diffusion was retarded (Kagan et al., 2017)
Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate -lyase pathway
Results DMF activates the TSS pathway in SCD erythroblasts To investigate the mechanism of DMF on ferroptosis regulation, we conducted untargeted LC-MS using erythroblasts generated from CD34+ stem cells isolated from the peripheral blood of SCD patient