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By working with neurotransmitters, mood regulation circuits, and possibly the hypothalamic-pituitary axis, DSIP may help reduce excessive stress hormones (like cortisol) and reduce the nervous systems on-edge state

This is a very interesting compound

This is the second large and under-discussed divergence between the DSIP literature and contemporary practice, and it compounds the dose gap described above

The more pragmatic question is whether peptides can complement biologic therapy, potentially improving outcomes or allowing dose reduction

Some peptides regulate the hypothalamic-pituitary-gonadal axis more directly, optimizing gonadotropin release patterns and normalizing downstream hormone production