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(7) The impact can be even more pronounced in older men, whose hormonal reserves are already declining

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301 In hepatic tissue, homocysteine has been shown to activate autophagy by downregulating cystic fibrosis transmembrane conductance regulator (CFTR) expression through the coordinated action of DNA methylation and EZH2-mediated H3K27me3, revealing epigenetic crosstalk between methylation pathways in autophagy regulation

It assists in offloading senescent cells, promotes cell survival, and stimulates repair mechanisms among all cells via high-grade autophagy, DNA repair, protections of the epigenome, methylation support, and diminished inflammation and LDL oxidation

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Physiol Rev 97:553622