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doi: 10.1016/j.biopha.2017.10.082 58
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These results suggest that while oxidative stress (GSH) is a strong indicator of the diabetic status vitamin B 12 deficiency, on the other hand, has little to do with either GSH or diabetes
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Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively