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A quick extrapolation of the statistics from Thun et al and Jha et al would relate that smoking related diseases, associated with just lung, heart and vascular ailments, pose an economic cost burden to the US GDP in the hundreds of billions of dollars, annually

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Other similar studies have used pseudo-reference regions for PET analysis, [14, 20, 85,86,87,88] but this method would not have been appropriate due to the hypothesized and confirmed effect of HIV and smoking throughout the brain regions tested