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1a), accompanied by impaired mitochondrial respiration as one of the main adverse molecular events (Suppl

10.1042/bj20130144 49 FroschauerE

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To avoid capturing donor-specific changes, we applied correlation and differential expression analyses for each of the six brain donors separately, and effect sizes were then combined by meta-analysis (metafor R-package 2.0)

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NADPH participates in biosynthetic reductions while NADH, which is not generated by the pentose phosphate shunt, is used primarily to donate electrons for oxidative phosphorylation to generate ATP