J Am Vet Med Assoc 2005;227:9549
Here, Zn II might be installed into an obligatory Zn II -dependent protein(s) by ZigA cotranslationally, into the nascent unfolded chain, thus avoiding kinetic or thermodynamic trapping of the metal into a holoprotein once folded
Whether preclinical nerve regeneration results translate to equivalent human outcomes is uncertain for all peptides except ARA-290, which has direct human data
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B12 deficiency can result in persistent fatigue, weakness, and slowing metabolism which can lead to weight gain