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174 Interestingly, some emerging evidence suggests protein restriction may not be as important for patients being treated with RAAS inhibitors and SGLT2 inhibitors, and several leading guidelines do not recommend any protein restriction for people with CKD, although excess protein intake is often discouraged

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Because Dihexa initiates synaptic structural changes that take hours to days to fully developrather than producing immediate neurotransmitter effectssplitting the daily dose provides no pharmacodynamic advantage

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