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In controlled Phase 3 trials of HUMIRA (40 mg SC every other week) in subjects with RA, PsA, and AS with control period duration ranging from 4 to 104 weeks, ALT elevations 3 x ULN occurred in 3.5% of HUMIRA-treated subjects and 1.5% of control-treated subjects

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Identification of 5-Hydroxycotinine in the plasma of nicotine-treated mice: implications for cotinine metabolism and disposition in vivo