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It has been reported that mutant p53 protein can negatively impact the cytotoxic effects of cisplatin treatment for NSCLC via the upregulation of NRF2, a transcription factor that was reported to contribute to the resistance of malignant cells to several anti-cancer drugs [205]

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CBDs sleep-supporting properties are relevant here reducing the anxiety that interferes with sleep onset and supporting the bodys natural circadian regulation

A separate but related parameter, filter pressure drop, is directly related to smoke delivery and filter efficiency (Norman 1999)

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