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Furthermore, iron overload triggers an oxidative stress cascade that disrupts intestinal immune homeostasis and barrier function in mammalian hosts, leading to gut microbiota dysbiosis characterized by decreased abundance of probiotics (Gu et al., 2023

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Our animal experiments revealed that the therapeutic effect of ACE surpasses that of established ferroptosis-inducing drugs and is superior to that of first-line clinical drugs such as capecitabine and TAS-102

wiping away the mark with HDAC2 or cutting glycolysis halts new-vessel sprouting, showing that H3K9la is an epigenetic regulator for tumor angiogenesis [171]