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Hammond DA, Sacha GL, Bissell BD, Musallam N, Altshuler D, Flannery AH, et al

Mechanism of Action 5-Amino-1MQs mechanism centers on selective inhibition of nicotinamide N-methyltransferase, with downstream metabolic effects mediated through changes in cellular methyl-donor availability, NAD + precursor flux, and adipocyte energy expenditure

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This bimodal effect of Agm in avoidance learning suggests that discrepancies between studies in spatial and recognition learning may simply reflect differences in the effective Agm dosage (or perhaps Glu/Agm ratio) experienced by the hippocampus

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