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Furthermore, disordered protein translation and signaling in the placenta can also cause ER stress in the syncytiotrophoblast, and has been demonstrated in placentas of IUGR patients [187]

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PMID 10333162

Among the different available methods, MM/GBSA method linked with MD simulations provides a good balance between computational efficiency and accuracy to compute the binding free energy 74

R.YadavS.DhaliwalJ.YadavM.KondepudiK

Drabsch Y, He S, Zhang L, Snaar-Jagalska BE, ten Dijke P