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combined use is speculative and may compound adverse metabolic and gastrointestinal effects with no safety framework to guide dosing

Similar clinical symptoms are found in individuals with hereditary IF deficiency (also called congenital pernicious anemia) in whom the lack of IF results in the defective absorption of vitamin B 12

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Gel formulations of vitamin B12 are somewhat new and applied into the nostrils (intranasally)

Subcutaneous injection was chosen as 5A-1MQ specifically has poor oral bioavailability in mice, a phenomenon that does not occur in rats 26