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We identified 22 Cochrane systematic reviews on behavioural interventions, pharmacotherapies, combined behavioural and pharmacotherapy interventions, and other interventions.22 We updated our search in June 2024, and findings on benefits and harms were consistent with results from earlier searches (Appendix 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)

Protection: Metal rods inside keep the cigarettes securely in place

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These filters are for use with standard sized cigars or roll ups with 7mm filter tips and are re-useable

These layers of unaddressed complexities undermine the premise of studies reinvestigating hemiacetals utilizing human reported safe levels of use

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