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Piyathilake CJ, Macaluso M, Chambers MM, Badiga S, Siddiqui NR, Bell WC, et al

Surprisingly, very similar prediction results with AUROC = 0.80 was established in this external validation cohort, suggesting that these microbiome features can be used to distinguish and predict human TMAO producer phenotypes from carnitine metabolism and have adequate potential to be applied in different populations

So this pathway sits on both sides of the ledger, part of the proposed mechanism of action and a candidate compensation route over the long haul

This decline correlates with observable decreases in tissue repair capacity

They either occur naturally or are created in the lab

Laboratory best practice calls for working with the compound in a low-humidity environment and minimizing exposure to oxidizing conditions