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CAN is characterized by damage to the nerve fibers that innervate the heart and blood vessels, leading to reduced heart rate variability (variability in the time interval between heartbeats) and increased risk of mortality (80)

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Mechanically-gated ion channels that respond to physical forces such as tension or pressure on the cell membrane

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Preclinical studies in rodents show it enhances synaptic connectivity and spatial memory retention with reported potency millions of times greater than BDNF