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Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

All animal experiments were approved by the Laboratory Animal Management and Ethics Committee of Fujian Medical University with approved number IACUC FJMU 2023-Y-0719 and were performed in accordance with the China Guide for the Protection and Use of Laboratory Animals

BPC-157 is a stable 15-amino-acid peptide derived from a human gastric protein