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For the first 14 weeks of the study, participants received cagrilintide and semaglutide as 2 separate injections in the stomach area

Like any medication, it can have side effects, some of which may affect the heart

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Reported side effects are typically mild and transient: BPC-157: Nausea (rare), mild fatigue in the first week, minor injection site redness TB-500: Mild lethargy during the loading phase, transient head rush immediately after injection, injection site discomfort Combined stack: No documented synergistic toxicity in preclinical or clinical observational data The more significant risks relate to sourcing and administration rather than the peptides themselves

Cell 173 , 822837 (2018)