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Hypoxia-inducible factor 1: master regulator of O2 homeostasis

The underlying mechanisms include ferroptosis and anticancer effects by regulating core signaling pathways such as the PI3K/Akt/mTOR, JAK/STAT, MAPK and Wnt/-catenin pathways (Fig

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The functional GDH is a hexamer structure composed of two sets of trimers, with each trimer containing ~ 500 amino acids and each monomer possessing a guanosine triphosphate (GTP) binding site and a nicotinamide adenine diphosphate hydride (NADH)/adenosine diphosphate (ADP) binding site, enabling binding of 6 GTP molecules, 6 ADP molecules and 6 NADH molecules with GDH hexamer at its respective allosteric binding sites

Milk thistle (also called holy thistle, Mary thistle, Marian thistle, or ladys thistle) is a herbal remedy derived from a plant called Silybum marianum or Carduus marianus