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This may be due, in part, to the elevated endogenous levels of G-CSF we observed in the plasma of smokers, perhaps as a result of cigarette smoke-induced damage to bronchial epithelial cells 60 , since this increases myelopoiesis

Due to the controlled, at-home environment of participation, we were ethically restricted from asking participants of their smoking status and experiences, and were unable to assess participant responses in real-world scenarios

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28 The choice of therapy should take into account the efficacy of treatment, the convenience of the dosing regimen and the side effect profile that match the patients values and preferences