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Most researchers find that the extra adaptation time makes the subsequent increase much more tolerable

That means using it is not just an unproven gamble on a supplement with limited evidence for competitive athletes, it is also a potential anti-doping violation

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2015 May;142(10):181830

Of note, pantothenic acid (formerly vitamin B 5 ) is the precursor of coenzyme A, and pyridoxine (vitamin B 6 ), in the form of pyridoxal-5'-phosphate, is required for the conversion of tyrosine to 4-hydroxyphenylpyruvic acid that constitutes the first step in the biosynthesis of the benzoquinone structure of coenzyme Q 10

Yan et al., 2019)