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Theres no exact timeframe, but patterns that continue for months or years especially with increased tolerance or cravings typically indicate chronic use

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Weinberg JM, Vafaie J, Scheinfeld NS

Abnormal heartbeat means that your heart beats too quickly, too slowly, or with an irregular pattern

Speak with a healthcare professional if your postnasal drip lasts more than 3 weeks or your foul-smelling mucus is yellow, green, or grey