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In this context, HIV-1 intron-containing RNA (icRNA)the unspliced, intron-retaining transcript that is Rev/RRE-dependent and exported via CRM1is detectable in previously infected CD4 T cells, macrophages, and microglia

Critically, it does not bind to the growth hormone receptor and does not raise IGF-1 levels.[1] This means its effects stay localized to fat metabolism, making it a much more targeted option than full hGH therapy

More is not better

IGF-1 is mostly produced by the liver and delivered into the bloodstream, Its physiological function is generally controlled by IGF-1 receptor and IGF-binding proteins

doi: 10.1016/j.fertnstert.2004.07.960

Cell Death Dis 8 (3), e2716