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131,132 In OA patients, similar changes have been confirmed in chondrocytes, partially attributed to variations in the expression of Dnmts (methylation) and Tet (demethylation) enzymes involved in methylation and demethylation processes, respectively

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A study showed that although individuals with Parkinsons disease have similar IGF-1 levels to healthy controls, those patients in the lowest IGF-1 quartile had lower performance on cognitive tasks assessing executive function, attention, and verbal memory (99)