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In addition to the catalytic function of PCBD1, the protein serves as a transcriptional co-activator for two transcription factors of the hepatocyte nuclear factor-1 family, HNF-1 (encoded by the HNF1A gene) and HNF-1 (encoded by the HNF1B gene)

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The mice they used have a mutation in the gene superoxide dismutase 1 (SOD1) which causes them to develop a condition which is similar to that of human ALS

The abdominal wall and skin were then closed using continuous sutures for each layer

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