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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis

They are recommended for people who have trouble absorbing B12 from food, such as those with digestive issues, vegans, or older adults

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With a sample size of 90 animals, our study is larger than prior ovine studies, including a critical validation cohort to confirm reliability of identified putative biomarkers

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