Because IM injections send B12 directly into muscle, the vitamin peaks in blood within about an hour, ensuring tissues get what they need
More preliminary findings, documented but less consistently replicated: FAK-paxillin pathway: Research has identified activation of the focal adhesion kinase (FAK) and paxillin signalling pathway, involved in cell migration and tissue organisation in laboratory models
Complete dosing chart at 10mg/ml (1ml of bacteriostatic water) Notice the problem at the 1.25mg microdose level
[DOI] [PubMed] [Google Scholar] 32.Zemba Cilic A., Zemba M., Cilic M., Balenovic I., Strbe S., Ilic S., Vukojevic J., Zoricic Z., Filipcic I., Kokot A., et al
J Pharm Sci
StatPearls notes that high-dose oral B has been shown effective for maintenance, but recommendations are to always use the parenteral route in severe neurological manifestations