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XuNDuCYuYLiYGaoSYuSet al
In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate
( B ) This decrease in GSH:GSSG is accompanied by increased expression of 15LO1 ( n = 4)
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Discussion While it is well accepted that EtOH-associated oxidative stress is a key mediator in the pathogenesis of ALD, the molecular details governing this process remain incompletely understood
Increased ACSL4 expression is observed in tumors, particularly triple-negative breast cancer, where higher ACSL4 levels may enhance sensitivity to radiotherapy and chemotherapy [31]
